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La PDE5 è la fosfodiesterasi predominante nei vasi polmonari. L’inibizione della PDE5 da parte di tadalafil aumenta le concentrazioni della cGMP determinando un rilassamento della muscolatura liscia dei vasi polmonari e una vasodilatazione del letto vascolare polmonare.

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Erektil disfonksiyon, çağımızın yaygın sağlık problemlerinden biri haline gelmiştir ve bu durumun tedavisinde kullanılan ilaçlar arasında Viagra önemli bir yere sahiptir. Viagra, aktif bileşeni sildenafil sitrat olan ve cinsel fonksiyon bozukluklarının giderilmesinde başarıyla kullanılan bir ilaçtır.

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